Rational design of neutralising antibodies resilient to virus escape

01.01.2022 – 31.12.2023

Summary

Scientific abstract

The current outbreak of a previously unknown betacoronavirus, SARS-CoV-2, started in 2019 in the city of Wuhan, China. Within a few weeks it reached pandemic proportions. As of today, virtually every country was involved and the virus caused over 160 million infections, claiming millions of lives. SARS-CoV-2 is the third coronavirus to cause outbreaks in less than twenty years. However, unlike the previous two, SARS-CoV-2 w...

Persons

Applicants

  • Andrea Cavalli, Istituto di ricerca in biomedicina (IRB) Facoltà di scienze biomediche Università della Svizzera italiana, Switzerland
  • Davide Robbiani, Institute for Research in Biomedicine (IRB) Università della Svizzera italiana (USI), Switzerland

Employees

Disciplines and keywords

mySNF disciplines (provided by researchers): Molecular Biology, Immunology, Immunopathology
Fields of research (mapped from mySNF Disciplines): Biological Sciences, Immunology
Keywords: monoclonal antibodies, emerging coronaviruses, SARS-CoV-2 variants, computational structural biology, SARS-CoV-2 therapy, protein engineering

Scientific publications

Neutralisation activity of mucosal IgA against XBB sublineages and BA.2.86

Zuo, Fanglei; Cao, Yunlong; Sun, Rui; Yisimayi, Ayijiang; Du, Likun; Bertoglio, Federico; Schubert, Maren; Guerra, Concetta; Cavalli, Andrea; Hust, Michael; Robbiani, Davide F; Abolhassani, Hassan; Xie, Xiaoliang Sunney; Hammarström, Lennart; Marcotte, Harold; Pan-Hammarström, Qiang
Neutralisation activity of mucosal IgA against XBB sublineages and BA.2.86. In The Lancet Infectious Diseases, 24(1), e7–e9.
2024
, Open Access

Conversion of monoclonal IgG to dimeric and secretory IgA restores neutralizing ability and prevents infection of Omicron lineages

Marcotte, Harold; Cao, Yunlong; Zuo, Fanglei; Simonelli, Luca; Sammartino, Josè Camilla; Pedotti, Mattia; Sun, Rui; Cassaniti, Irene; Hagbom, Marie; Piralla, Antonio; Yang, Jinxuan; Du, Likun; Percivalle, Elena; Bertoglio, Federico; Schubert, Maren; Abolhassani, Hassan; Sherina, Natalia; Guerra, Concetta; Borte, Stephan; Rezaei, Nima; Kumagai-Braesch, Makiko; Xue, Yintong; Su, Chen; Yan, Qihong; et al.,
Conversion of monoclonal IgG to dimeric and secretory IgA restores neutralizing ability and prevents infection of Omicron lineages. In Proceedings of the National Academy of Sciences, 121(3), 1–11.
2024
, Open Access

Human neutralizing antibodies to cold linear epitopes and subdomain 1 of the SARS-CoV-2 spike glycoprotein

Bianchini, Filippo; Crivelli, Virginia; Abernathy, Morgan E.; Guerra, Concetta; Palus, Martin; Muri, Jonathan; Marcotte, Harold; Piralla, Antonio; Pedotti, Mattia; De Gasparo, Raoul; Simonelli, Luca; Matkovic, Milos; Toscano, Chiara; Biggiogero, Maira; Calvaruso, Veronica; Svoboda, Pavel; Cervantes Rincón, Tomás; Fava, Tommaso; Podešvová, Lucie; Shanbhag, Akanksha A.; Celoria, Andrea; Sgrignani, Jacopo; Stefanik, Michal; Hönig, Vaclav; et al.,
Human neutralizing antibodies to cold linear epitopes and subdomain 1 of the SARS-CoV-2 spike glycoprotein. In Science Immunology, 8(81), 1–17.
2023
, Open Access

Autoantibodies against chemokines post-SARS-CoV-2 infection correlate with disease course

Muri, Jonathan; Cecchinato, Valentina; Cavalli, Andrea; Shanbhag, Akanksha A.; Matkovic, Milos; Biggiogero, Maira; Maida, Pier Andrea; Moritz, Jacques; Toscano, Chiara; Ghovehoud, Elaheh; Furlan, Raffaello; Barbic, Franca; Voza, Antonio; De Nadai, Guendalina; Cervia, Carlo; Zurbuchen, Yves; Taeschler, Patrick; Murray, Lilly A.; Danelon-Sargenti, Gabriela; Moro, Simone; Gong, Tao; Piffaretti, Pietro; Bianchini, Filippo; Crivelli, Virginia; et al.,
Autoantibodies against chemokines post-SARS-CoV-2 infection correlate with disease course (24).
2023

Heterologous inactivated virus/mRNA vaccination response to BF.7, BQ.1.1, and XBB.1

Zuo, Fanglei; Sun, Rui; Abolhassani, Hassan; Du, Likun; Wang, Yating; Vlachiotis, Stelios; Bertoglio, Federico; Schubert, Maren; Rezaei, Nima; Chavoshzadeh, Zahra; Guerra, Concetta; Cavalli, Andrea; Andréll, Juni; Kumagai-Braesch, Makiko; Xue, Yintong; Cao, Yunlong; Hust, Michael; Robbiani, Davide F.; Xie, Xiaoliang Sunney; Hammarström, Lennart; Marcotte, Harold; Pan-Hammarström, Qiang
Heterologous inactivated virus/mRNA vaccination response to BF.7, BQ.1.1, and XBB.1. In The Lancet Regional Health - Western Pacific, 33, 100762–100762.
2023
, Open Access

Collaboration

Daniel Ruzek/Biology Centre of the Czech Academy of Sciences

  • in-depth/constructive exchanges on approaches, methods or results
Czech Republic

Overview

Grant number
203488
Funding scheme
Bridge - Discovery
Call
Bridge - Discovery Full proposal 2021
Approved amount
411,520 CHF
Status
Completed
Research institution
Università della Svizzera italiana – USI
Institute
Istituto di ricerca in biomedicina (IRB) Facoltà di scienze biomedice

Output data