Role of lymphatic endothelial cells in Autoimmunity and Cancer

01.09.2019 – 31.12.2023

Summary

Scientific abstract

Lymph nodes (LNs) are specialized organs draining the lymph flow and orchestrating antigen (Ag) specific adaptive immunity. LN stromal cells (LNSCs) release soluble factors that facilitate the migration and interactions between hematopoietic cells, and the homeostasis of immune cells. In addition, two particular subtypes, the fibroblastic reticular cells (FRCs) and lymphatic endothelial cells (LECs), express Ags otherwise r...

Persons

Applicants

  • Stephanie Hugues, Département de Pathologie et Immunologie Faculté de Médecine / CMU Université de Genève, Switzerland

Disciplines and keywords

mySNF disciplines (provided by researchers): Immunology, Immunopathology, Cellular Biology, Cytology
Fields of research (mapped from mySNF Disciplines): Immunology, Biochemistry and cell biology
Keywords: regulatory T cell, antigen-presentation, mouse models, cancer, autoimmunity, human samples, T lymphocyte, lymphatic endothelial cells

Overview

Grant number
185255
Funding scheme
Project funding
Call
Project funding in biology and medicine (division III) 2018 October
Approved amount
759,360 CHF
Status
Completed
Research institution
University of Geneva - GE
Institute
Département de Pathologie et Immunologie Faculté de Médecine / CMU Université de Genève