Role of lymphatic endothelial cells in Autoimmunity and Cancer
01.09.2019 – 31.12.2023
Summary
Scientific abstract
Lymph nodes (LNs) are specialized organs draining the lymph flow and orchestrating antigen (Ag) specific adaptive immunity. LN stromal cells (LNSCs) release soluble factors that facilitate the migration and interactions between hematopoietic cells, and the homeostasis of immune cells. In addition, two particular subtypes, the fibroblastic reticular cells (FRCs) and lymphatic endothelial cells (LECs), express Ags otherwise r...
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Persons
Applicants
- Stephanie Hugues, Département de Pathologie et Immunologie Faculté de Médecine / CMU Université de Genève, Switzerland
Disciplines and keywords
mySNF disciplines (provided by researchers): Immunology, Immunopathology, Cellular Biology, Cytology
Fields of research (mapped from mySNF Disciplines): Immunology, Biochemistry and cell biology
Keywords: regulatory T cell, antigen-presentation, mouse models, cancer, autoimmunity, human samples, T lymphocyte, lymphatic endothelial cells