Characterization and functional relevance of CD20-positive T cells in multiple sclerosis

01.06.2016 – 30.11.2017

Summary

Scientific abstract

Multiple sclerosis (MS) is a chronic, inflammatory, demyelinating disease of the central nervous system (CNS) that affects approximately 10,000 people in Switzerland and >2.5 million people worldwide. It is thought to be caused by a complex interplay of genetic and environmental factors (infections, Vitamin D, gut microbiome, and others). Both experimental and clinical evidence suggest that autoreactive B and T cells are ke...

Persons

Applicants

Disciplines and keywords

mySNF disciplines (provided by researchers): Immunology, Immunopathology, Neurophysiology and Brain Research, Neurology, Psychiatry
Fields of research (mapped from mySNF Disciplines): Immunology, Neurosciences, Neurosciences
Keywords: neurology, autoimmunity, multiple sclerosis, B cells, T cells, immunology

Scientific publications

Recirculating Intestinal IgA-Producing Cells Regulate Neuroinflammation via IL-10

Rojas, Olga L.; Pröbstel, Anne-Katrin; Porfilio, Elisa A.; Wang, Angela A.; Charabati, Marc; Sun, Tian; Lee, Dennis S.W.; Galicia, Georgina; Ramaglia, Valeria; Ward, Lesley A.; Leung, Leslie Y.T.; Najafi, Ghazal; Khaleghi, Khashayar; Garcillán, Beatriz; Li, Angela; Besla, Rickvinder; Naouar, Ikbel; Cao, Eric Y.; Chiaranunt, Pailin; Burrows, Kyle; Robinson, Hannah G.; Allanach, Jessica R.; Yam, Jennifer; Luck, Helen; et al.,
Recirculating Intestinal IgA-Producing Cells Regulate Neuroinflammation via IL-10. In Cell, 176(3), 610–624.e18.
2019
, Open Access

Association of antibodies against myelin and neuronal antigens with neuroinflammation in systemic lupus erythematosus

Pröbstel, Anne-Katrin; Thanei, Madlaina; Erni, Barbara; Lecourt, Anne-Catherine; Branco, Léonore; André, Raphaël; Roux-Lombard, Pascal; Koenig, Katrin F; Huynh-Do, Uyen; Ribi, Camillo; Chizzolini, Carlo; Kappos, Ludwig; Trendelenburg, Marten; Derfuss, Tobias
Association of antibodies against myelin and neuronal antigens with neuroinflammation in systemic lupus erythematosus. In Rheumatology, 58(5), 908–913.
2019

Peripheral neuropathy in antineutrophil cytoplasmic antibody-associated vasculitidesInsights from the DCVAS study

Bischof, Antje; Jaeger, Veronika K.; Hadden, Robert D. M.; Luqmani, Raashid A.; Pröbstel, Anne-Katrin; Merkel, Peter A.; Suppiah, Ravi; Craven, Anthea; Collins, Michael P.; Daikeler, Thomas
Peripheral neuropathy in antineutrophil cytoplasmic antibody-associated vasculitidesInsights from the DCVAS study. In Neurology - Neuroimmunology Neuroinflammation, 6(6), e615–e615.
2019
, Open Access

Multiple Sclerosis-Associated Changes in the Composition and Immune Functions of Spore-Forming Bacteria

Cekanaviciute, Egle; Pröbstel, Anne-Katrin; Thomann, Anna; Runia, Tessel F.; Casaccia, Patrizia; Katz Sand, Ilana; Crabtree, Elizabeth; Singh, Sneha; Morrissey, John; Barba, Patrick; Gomez, Refujia; Knight, Rob; Mazmanian, Sarkis; Graves, Jennifer; Cree, Bruce A. C.; Zamvil, Scott S.; Baranzini, Sergio E.
Multiple Sclerosis-Associated Changes in the Composition and Immune Functions of Spore-Forming Bacteria. In mSystems, 3(6), e00083-18.
2018
, Open Access

Oligodendrocyte-encoded Kir4.1 function is required for axonal integrity

Schirmer, Lucas; Möbius, Wiebke; Zhao, Chao; Cruz-Herranz, Andrés; Ben Haim, Lucile; Cordano, Christian; Shiow, Lawrence R; Kelley, Kevin W; Sadowski, Boguslawa; Timmons, Garrett; Pröbstel, Anne-Katrin; Wright, Jackie N; Sin, Jung Hyung; Devereux, Michael; Morrison, Daniel E; Chang, Sandra M; Sabeur, Khalida; Green, Ari J; Nave, Klaus-Armin; Franklin, Robin JM; Rowitch, David H
Oligodendrocyte-encoded Kir4.1 function is required for axonal integrity. In eLife, 7, e36428.
2018
, Open Access

Multiple Sclerosis: B cells Take Center Stage

Pröbstel Anne-Katrin, Hauser Stephen L.
Multiple Sclerosis: B cells Take Center Stage. In Journal of Neuroophthalmology, na.

Collaboration

Karin Lab, UCSD

  • in-depth/constructive exchanges on approaches, methods or results
  • Publication
United States of America

Conner Lab, BMC

  • in-depth/constructive exchanges on approaches, methods or results
  • Publication
United States of America

iMSMS

  • in-depth/constructive exchanges on approaches, methods or results
  • Publication
  • Research Infrastructures
United States of America

Gommerman Lab, University of Toronto

  • in-depth/constructive exchanges on approaches, methods or results
  • Publication
Canada

Academic events

ACTRIMS Forum 2018

Type: Poster
Title of contribution: Immunoglobulin A is a critical regulator of demyelinating neuroinflammation.
01.02.2018
, San Diego, United States of America

Cell Symposium NextGenImmunology

Type: Poster
Title of contribution: Immunoglobulin A is a critical regulator of demyelinating neuroinflammation
01.02.2018
, Rehovot, United States of America

UCSF/UCB Immunology Retreat

Type: Talk given at a conference
Title of contribution: Gut-brain axis: Dissecting the cross-talk between B cells and microbiome multiple sclerosis
22.09.2017
, Asilomar, United States of America

Knowledge transfer events

Awards

ACTRIMS Forum Best Poster Presentation Award

2019

National MS Society Young Investigator Award

2019

ECTRIMS Young Investigator Travel Award

2018

ACTRIMS Forum Young Investigator Award

2018

ECTRIMS-ACTRIMS Young Investigator Travel Award

2017

ECTRIMS Young Investigator Travel Award

2016

Overview

Grant number
164938
Funding scheme
Early Postdoc.Mobility
Call
Early Postdoc.Mobility 2015 (01.09.2015)
Approved amount
75,650 CHF
Status
Completed
Institute
von Büdingen Lab University of California San Francisco(UCSF), United States of America

Output data