Alternative sigma factors in Staphylococcus aureus

01.05.2003 – 31.05.2007

Summary

Scientific abstract

This project aimed at the identification and characterization of the two alternative transcription factors Sigma B and Sigma H of Staphylococcus aureus. While Sigma H was found to control a very small regulon, encompassing the genes SA1374 and SA1418 only, and appeared to be inactive under all in vitro conditions analyzed, Sigma B was found to control a large regulon of at least 251 genes/operons in response to en...

Persons

Applicants

Markus Bischoff, Institut für Medizinische Mikrobiologie und Hygiene Universitätsklinikum des Saarlandes, Germany

Employees

Alexis Dumoulin
Stefan Meier, Institut für Medizinische Mikrobiologie Universität Zürich, Switzerland
Bettina Schulthess, Institut für Medizinische Mikrobiologie Universität Zürich, Switzerland

Disciplines and keywords

mySNF disciplines (provided by researchers): Medical Microbiology

Fields of research (mapped from mySNF Disciplines): Medical microbiology

Keywords: alternative sigma factors, Sigma B, Sigma H, regulation of virulence determinant production, antibiotic- and stress resistance

Overview

Grant number

100234

Funding scheme

Project funding

Call

Approved amount

191,090 CHF

Status

Completed

Research institution

University of Zurich – ZH

Institute

Institut für Medizinische Mikrobiologie Universität Zürich